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Progressive Multifocal Leukoencephalopathy After Natalizumab Monotherapy NEJM 361:1081-1087, Linda,H.,et al, 2009 See this aricle in Pubmed Article Abstract We describe progressive multifocal leukoencephalopathy (PML) caused by infection with human polyomavirus JC virus in patient with multiple sclerosis who was treated with natalizumab. Approximately 3 weeks after plasma exchange, an immune-reconstitution inflammatory syndrome appeared. JC virus DNA was no longer detectable on quantitative PCR assay, and the patient�s symptoms improved.

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(click to filter results - removes previous filter) iatrogenic neurologic disorders immune reconstitution inflammatory syndrome monoclonal antibodies MRI MRI,abnormal multiple sclerosis multiple sclerosis,treatment of natalizumab opportunistic infection opportunistic infection,CNS plasmapheresis polymerase chain reaction polymerase chain reaction,false negative prognosis progressive multifocal leucoencephalopathy

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